Inhaltsstoffe:

Kava-Pyrone mit dem Hauptwirksoff Kavain

Wirkung:

Wirkungssort ist die Formatio reticularis des Hirnstammes, die Stelle, die alle Hirnbereiche miteinander verschaltet. Hier wirkt der Rauschpfeffer beruhigend, dämpft die Nervosität und wirkt stimulierend. Parallel ist eine, die Muskeln entspannende Wirkung, zu verzeichnen, die sich durch die Kombination mit Pestwurz noch verstärken lässt. Außerdem wurde eine lokalanästhesierende Wirkung auf die Magen-, Nieren- und Blasenschleimhaut nachgewiesen, weshalb Kava-Kava auch bei Prostatabeschwerden mit Erfolg eingesetzt wird.

Dieser Teil leider noch auf English

Synonyms

Kava; Kava-Kava; Kawa-Kawa; Methysticum

Definitions:

Piper Methysticum is the peeled, dried rhizome and root of Piper methysticum Forster (Fam. Piperaceae) a plant indigenous to, and cultivated in, the South Sea Islands from Hawaii to the East Indies.

Piper Methysticum contains about 5% of a resin composed of a number of closely related 5,6-dihydro-a-Pyrones, including yangonin, desmoethyl-oxy-yangonin, kawain, dihydro-kawain, methysticin and dihydromethysticin, together with two glycosides, mucilage and sugar.

B.P.C. (1934) p. 573.

Description:

Macroscopical:

Irregular pieces of rhizome, transversely and longitudinally cut, 3-20 cm long, 1-10 cm in diameter. Light yellow-brown, longitudinally wrinkled with large, white, circular root scars. Fracture short and granular, inner surface yellow-white, bark thin, xylem distinctly radiate, pith large. Stem fragments narrower, up to 3 cm in diameter and hollow. Odour slight; taste sweet then pungent followed by a slight numbness.

Microscopical:

Light yellow-brown powder, large oval cells of the pith; starch grains numerous spheroidal up to 45 mm in diameter, 2-3 compound or single, hilum central and cleft. Secretion canals containing yellow to red-brown masses of resin ; elongated cells of the medullary rays porous and slightly lignified.

Vessels lignified, reticulate; fibres slightly lignified, large lumen and occasionally branched oval ends. Xylem parenchyma, cells lignified and slightly elongated. Calcium oxalate and cork absent.

Total Ash

Total Ash: Not more than 8%.

Identification Tests:

(a) A drop of sulphuric acid applied to the powder on a tile produces a cherry- red colour.

(b) Mount the powder in absolute alcohol and partially evaporate the solvent.

Prismatic crystals of methysticin appear at the edges of the cover slip. These crystals polarise red-violet to yellow and dissolve in sulphuric acid with the formation of a violet solution.

Chromatography:

Hansel, R. and Beiersdorff, H. A. (1955) Arzneimittel-forsch 9, 581-585.

Therapeutics:

Action: Anti-microbial. Diuretic. Spasmolytic. Sedative Carminative.

Action Topically: - Rubefacient.

Indications:Cystitis. Urethritis. Rheumatism. Joint pains - topical application.

Specific Indications:Infection of genito- urinary tract.

Combinations Used:Combines with Althaea Root, Apium and Agropyron in bladder disease; with Menyanthes, Cimicifuga and Apium in rhematism.

Preparation and Dosage: (thrice daily)

Dried Root: Dose 2-4 g or by decoction.

Liquid

This excerpt has been posted by permission of Healthlink from http://www.healthlink.com.au/nat_lib/htm-data/htm-herb/bhp702.htm

NAME : Kawain
CHEMICAL NAME : [R-(E)]-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one
ALTERNATE CHEMICAL NAMES : 5-hydroxy-3-methoxy-7-phenyl-2,6-heptadienoic acid delta-lactone;
4-methoxy-6-(ß-phenylvinyl)-5,6-dihydro-alpha-pyrone
ALTERNATE CHEMICAL NAMES : 4-methoxy-6-styryl-5,6-dihydro-alpha-pyrone; kavain; gonosan
CHEMICAL FORMULA C14H14O3
MOLECULAR WEIGHT 230.26
From the Merck Index 12th Edition

NAME : Methysticin
CHEMICAL NAME : [R-(E)]-6-[2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
ALTERNATE CHEMICAL NAMES : kavahin; kavatin
ALTERNATE CHEMICAL NAMES : 5-hydroxy-3-methoxy-7-[3,4-(methylenedioxy)phenyl]-2,6-heptadienoic acid delta-lactone
ALTERNATE CHEMICAL NAMES : 4-methoxy-6-[.beta.-(3',4'-methylenedioxyphenyl)vinyl]-5,6-dihydro-.alpha.-pyrone
ALTERNATE CHEMICAL NAMES : 6-(3',4'-methylenedioxystyryl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
CHEMICAL FORMULA C15H14O5
MOLECULAR WEIGHT 274.27
From the Merck Index 12th Edition
CAS # 9000-38-8

NAME : Yangonin
CHEMICAL NAME : (E)-4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one;
ALTERNATE CHEMICAL NAMES : 4-methoxy-6-(p-methoxystyryl)-2H-pyran-2-one;
4-methoxy-6-(ß-phenylvinyl)-5,6-dihydro-alpha-pyrone
ALTERNATE CHEMICAL NAMES : 5-hydroxy-3-methoxy-7-(p-methoxyphenyl)-2,4,6-heptatrienoic acid delta-lactone
ALTERNATE CHEMICAL NAMES : 4-methoxy-6-[beta-(p-anisyl)vinyl]-alpha-pyrone; 6-(p-methoxystyryl)-4-methoxy-alpha-pyrone
CHEMICAL FORMULA C15H14O4
MOLECULAR WEIGHT 258.27
MELTING POINT 155-157 C
From the Merck Index 12th Edition

Links to further information:

1. Kava: Nature's Answer to Stress, Anxiety, and Insomnia <hyla.htm>; Hyla Cass, M.D. and Terrence McNally; Rocklin, CA; Prima Publishing; 1998.
2. The Natural Pharmacy <NaturalPharmacy.htm>, Skye Lininger, D.C., Jonathan Wright, M.D., Steve Austin, N.D., Donald Brown, N.D., and Alan Gaby, N.D.; Rocklin, CA; Prima Publishing; 1998.
3. Kava, Nature's Relaxant for Anxiety, Stress, and Pain <contentsW.htm>; Hasnain Walji, Ph.D.; Prescott, AZ; Hohm Press; 1997.
4. Kava-The Pacific Elixir: The Definitive Guide to its Ethnobotany, History, and Chemistry; <elixir.htm> Vincent Lebot, Mark Merlin, and Lamont Lindstrom, Rochester, VT; Healing Arts Press; 1997.

 
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